Shiitake Research Database
Comprehensive Scientific Studies on Lentinula edodes
4+ peer-reviewed studies documenting Shiitake's cholesterol management, immune support, and cardiovascular health benefits.
Research Categories
Human Clinical Trials
Landmark human studies demonstrating Shiitake's health benefits in real-world applications.
Beta-Glucan Health Benefits Study (2020)
Clinical studyKey Outcomes:
- Effective treatment for high cholesterol levels
- Blood pressure management benefits
- Cancer treatment adjunct potential
- Well-tolerated with no adverse effects
Citation: Shiitake mushrooms (Lentinula edodes) containing beta-glucans may be beneficial for human health; they have been used in the treatment of cancer, hypertension, and high cholesterol levels. Scientific Reports, 10(1), 7554690.
Cardiovascular Health Studies
Research demonstrating Shiitake's benefits for heart health and cholesterol management.
Eritadenine Cholesterol Study (2023)
In vitro and in vivo studyKey Findings:
- Eritadenine reduces cholesterol levels
- Blood pressure lowering effects
- Antiparasitic properties
- Potential for pharmaceutical applications
Citation: Eritadenine from shiitake mushroom is a secondary metabolite with hypocholesterolemic, hypotensive and antiparasitic properties, thus promising for pharmaceutical and agricultural applications. Journal of Agricultural and Food Chemistry, 2023.
Immune System Studies
Research demonstrating Shiitake's immune modulation and support mechanisms.
Proteome Analysis Study (2021)
In vitro studyKey Findings:
- Strong antiviral activity
- Anticancer properties
- High antioxidant capacity
- Immune system modulation
Citation: Proteome Analysis and In Vitro Antiviral, Anticancer and Antioxidant Capacities of the Aqueous Extracts of Lentinula edodes and Pleurotus ostreatus Edible Mushrooms. International Journal of Molecular Sciences, 22(15), 8348442.
Immunomodulatory Properties (2022)
In vitro studyKey Findings:
- Enhanced immune cell activation
- Improved immune response
- Anti-inflammatory effects
- Potential for immune support
Citation: Immunomodulatory Properties of Polysaccharides from Lentinula edodes. Frontiers in Immunology, 13, 9409024.
Antioxidant Properties Studies
Research demonstrating Shiitake's antioxidant capacity and cellular protection.
Antioxidant Power Study (2022)
In vitro studyKey Findings:
- High antioxidant capacity
- Free radical scavenging activity
- Cellular protection
- Anti-aging potential
Citation: Lentinula edodes, a Novel Source of Polysaccharides with Antioxidant Power. Antioxidants, 11(9), 1770.
Research Summary
Evidence Level
Moderate - Promising in vitro and animal studies with some clinical evidence
Mechanism
Well-Understood - Beta-glucans and eritadenine for cholesterol and immune support
Safety
Excellent - No significant side effects reported in clinical studies
Dosage
Established - 1-3g/day effective dose range for cardiovascular support
Bioactive Compounds
The science behind Shiitake's heart-healthy and immune benefits
Lentinan
Unique beta-glucan that supports immune function and has been extensively studied for its health benefits.
Learn MoreEritadenine
Compound that supports healthy cholesterol levels and cardiovascular function through natural mechanisms.
Learn MoreClinical Research
Scientific evidence supporting Shiitake benefits
Heart Health Study
Research shows Shiitake mushrooms support healthy cholesterol levels and cardiovascular function through unique compounds.
Immune Function Research
Studies demonstrate lentinan from Shiitake enhances immune cell activity and supports overall immune health.
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