Lion's Mane Research Citations

Scientific Research Citations from PubMed Central

Note: Citations are organized by relevance and include study titles, authors, publication details, and direct links to full-text articles. Health-related studies include helpful FAQs that answer common questions about the research findings.
1
Polysorbate 80 Differentially Impacts Erinacine Production Profiles in Submerged Cultures of Hericium.
Authors: Smith AV, Zhu H, Mats L, Bozzo G.
Publication: Molecules. 2025 Jun 30;30(13):2823. doi: 10.3390/molecules30132823.
PMC12251483
2
Bioactive Polysaccharides from Hericium erinaceus: Extraction, Structure, Bioactivities, and Applications.
Authors: Ge F, Chen Y, Wang B, Zhou W, Du B, Hou L.
Publication: Molecules. 2025 Apr 20;30(8):1850. doi: 10.3390/molecules30081850.
PMC12029305

Frequently Asked Questions

This review study looked at the bioactive polysaccharides found in Lion's Mane and their various health applications. The research covers how these compounds are extracted, their structure, and their bioactivities - which include immune support, neuroprotective effects, and other health benefits. Read about the bioactivities.
This study reviewed different extraction methods for getting bioactive polysaccharides from Lion's Mane. The research discusses various extraction techniques and how they affect the structure and effectiveness of the beneficial compounds. Understanding extraction methods helps ensure you get the most beneficial compounds from Lion's Mane supplements. See the extraction methods.
3
Discovery of a New Compound, Erinacerin W, from the Mycelia of Hericium erinaceus, with Immunomodulatory and Neuroprotective Effects.
Authors: Lin JY, Chen YP, Lin TW, Li TJ, Chen YW, Li IC, Chen CC.
Publication: Molecules. 2024 Feb 9;29(4):812. doi: 10.3390/molecules29040812.
PMC10891892

Frequently Asked Questions

This study discovered a new compound called erinacerin W in Lion's Mane mycelium that has both immunomodulatory (affects your immune system) and neuroprotective (protects your brain cells) effects. The research found that this compound can help support immune function and protect nerve cells, which are two key benefits people look for in Lion's Mane. Learn about erinacerin W.
This research found that a compound called erinacerin W from Lion's Mane has immunomodulatory effects, meaning it can help regulate and support your immune system. The study showed that this compound affects immune function in a beneficial way, which explains one of the ways Lion's Mane supports overall health. Read about immune support.
This study discovered that erinacerin W, a compound in Lion's Mane, has neuroprotective effects. This means it can help protect your brain cells from damage, which is one of the main reasons people take Lion's Mane for cognitive health and brain support. See the neuroprotective research.
4

Frequently Asked Questions

This double-blind pilot study tested Lion's Mane supplementation in young adults and looked at both immediate (acute) and long-term (chronic) effects on cognitive function, stress, and mood. The research found effects on these areas, though as a pilot study, it's an early look at how Lion's Mane might help young adults with focus, stress management, and mood. See the study results.
This human study tested Lion's Mane supplementation in young adults and measured effects on stress and mood, in addition to cognitive function. The research looked at both short-term and longer-term effects, providing real-world data on how Lion's Mane might help with stress management and mood support. Read about stress and mood effects.
This study tested both acute (immediate) and chronic (long-term) effects of Lion's Mane supplementation, which helps answer the question of how quickly it works. The research looked at both short-term and extended use to see when benefits might appear, giving insight into both immediate and cumulative effects. See the timing of effects.
5
Neurotrophic and Neuroprotective Effects of Hericium erinaceus.
Authors: Szućko-Kociuba I, Trzeciak-Ryczek A, Kupnicka P, Chlubek D.
Publication: Int J Mol Sci. 2023 Nov 3;24(21):15960. doi: 10.3390/ijms242115960.
PMC10650066

Frequently Asked Questions

Neurotrophic means supporting the growth, survival, and function of nerve cells. This study reviewed how Lion's Mane has neurotrophic effects, which means it helps support your brain cells and nerve health. This is one of the key mechanisms behind why Lion's Mane is so popular for cognitive health and brain support. Learn about neurotrophic effects.
This research reviewed the neuroprotective effects of Lion's Mane, which means it helps protect your brain cells from damage. The study explains how Lion's Mane compounds work to shield your neurons, which is important for maintaining cognitive function and brain health as you age. Read about neuroprotection.
6
Unprecedented Neoverrucosane and Cyathane Diterpenoids with Anti-Neuroinflammatory Activity from Cultures of the Culinary-Medicinal Mushroom Hericium erinaceus.
Authors: Wei J, Li JY, Feng XL, Zhang Y, Hu X, Hui H, Xue X, Qi J.
Publication: Molecules. 2023 Aug 31;28(17):6380. doi: 10.3390/molecules28176380.
PMC10489798

Frequently Asked Questions

This study discovered new compounds in Lion's Mane called neoverrucosane and cyathane diterpenoids that have anti-neuroinflammatory activity. This means they can help reduce inflammation in your brain, which is important because brain inflammation is linked to cognitive decline and various neurological conditions. See the anti-inflammatory research.
This research found specific compounds in Lion's Mane called neoverrucosane and cyathane diterpenoids that have anti-neuroinflammatory effects. These compounds can help reduce inflammation in the brain, which is one way Lion's Mane supports brain health and cognitive function. Learn about the compounds.
7
Enrichment Extraction and Activity Study of the Different Varieties of Hericium erinaceus against HCT-8 Colon Cancer Cells.
Authors: Cao Z, Zhang Z, Wei D, Guo M, Li S, Cui H, Zhang Y, Zhang Y, Chen X.
Publication: Molecules. 2023 Aug 28;28(17):6288. doi: 10.3390/molecules28176288.
PMC10488996

Frequently Asked Questions

This study tested different varieties of Lion's Mane against colon cancer cells (HCT-8) and found that Lion's Mane extracts showed activity against these cancer cells. The research tested different extraction methods and varieties to see which were most effective, suggesting that Lion's Mane compounds might have anticancer properties. See the cancer research.
This research tested different varieties of Lion's Mane and found that they had different levels of activity against colon cancer cells. This suggests that the specific type or variety of Lion's Mane you use might matter for its health benefits, and some varieties may be more potent than others. Read about variety differences.
8
Commercial scale production of Yamabushitake mushroom (Hericium erinaceus (Bull.) Pers. 1797) using rubber and bamboo sawdust substrates in tropical regions.
Authors: Chutimanukul P, Phatthanamas W, Thepsilvisut O, Chantarachot T, Thongtip A, Chutimanukul P.
Publication: Sci Rep. 2023 Aug 16;13(1):13316. doi: 10.1038/s41598-023-40601-y.
PMC10432537
9
Hericium erinaceus, in combination with natural flavonoid/alkaloid and B3/B8 vitamins, can improve inflammatory burden in Inflammatory bowel diseases tissue: an ex vivo study.
Authors: Gravina AG, Pellegrino R, Palladino G, Coppola A, Brandimarte G, Tuccillo C, Ciardiello F, Romano M, Federico A.
Publication: Front Immunol. 2023 Jul 3;14:1215329. doi: 10.3389/fimmu.2023.1215329.
PMC10350490

Frequently Asked Questions

This study tested Lion's Mane in combination with other natural compounds and B vitamins on inflammatory bowel disease tissue and found that it helped reduce the inflammatory burden. The research showed that Lion's Mane, especially when combined with certain flavonoids, alkaloids, and B vitamins, can help improve inflammation in IBD. See the IBD research.
This research tested Lion's Mane alone and in combination with natural flavonoids, alkaloids, and B vitamins for inflammatory bowel disease. The study found that the combination worked better than Lion's Mane alone, suggesting that pairing Lion's Mane with certain other natural compounds might enhance its benefits for gut health and inflammation. Read about combinations.
10
Hericium erinaceus, a medicinal fungus with a centuries-old history: Evidence in gastrointestinal diseases.
Authors: Gravina AG, Pellegrino R, Auletta S, Palladino G, Brandimarte G, D'Onofrio R, Arboretto G, Imperio G, Ventura A, Cipullo M, Romano M, Federico A.
Publication: World J Gastroenterol. 2023 May 28;29(20):3048-3065. doi: 10.3748/wjg.v29.i20.3048.
PMC10280799

Frequently Asked Questions

This review study looked at the evidence for using Lion's Mane for gastrointestinal diseases. The research compiled evidence showing that Lion's Mane has been used for centuries for gut health and that modern studies support its use for various digestive conditions. Read about gastrointestinal benefits.
This comprehensive review examined the evidence for Lion's Mane in gastrointestinal diseases. The study looked at how Lion's Mane has been used historically and what modern research says about its effectiveness for various gut health issues, providing a thorough overview of its digestive benefits. See the digestive health evidence.