Nagano et al. (2010) Study Analysis
Clinical Trial: Depression, Anxiety & Cognitive Function
Lion's Mane (Hericium erinaceus) - Double-blind, Placebo-controlled RCT
Full Citation
Nagano, M., Shimizu, K., Kondo, R., Hayashi, C., Sato, D., Kitagawa, K., & Ohnuki, K. (2010). Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomedical Research, 31(4), 231-237.
DOI: 10.2220/biomedres.31.231 | PubMed ID: 20834180
Participants
- Total: 30 Japanese women
- Age Range: 40-60 years
- Condition: Menopausal symptoms, mild depression/anxiety
- Exclusion: Severe depression, medication use
Intervention
- Dosage: 250mg tablets, 3x daily
- Total Daily: 750mg
- Extract Type: Standardized H. erinaceus
- Duration: 4 weeks
- Placebo: Identical appearance
Study Design
- Type: Double-blind RCT
- Duration: 4 weeks treatment
- Primary Outcomes: Depression/anxiety scores, cognitive function
- Assessment: Standardized questionnaires
Primary Results
Depression Scores
Anxiety Scores
Function
Treatment Duration
Clinical Significance
This study demonstrates that Lion's Mane can support mood balance and cognitive function, showing benefits for both depression and anxiety symptoms. The relatively short 4-week duration suggests that Lion's Mane may provide relatively quick mood support benefits.
The study's focus on menopausal women suggests that Lion's Mane may be particularly beneficial during times of hormonal changes, when mood and cognitive function can be affected.
Safety Profile
- Adverse Events: None reported
- Tolerability: Excellent, well-tolerated
- Compliance: High adherence rate
What This Means for You
This research suggests that Lion's Mane may help support mood balance and reduce feelings of depression and anxiety. The study showed benefits after just 4 weeks of use, which is relatively quick compared to many mood-supporting supplements. While individual results may vary, this research indicates that Lion's Mane may be a valuable natural option for supporting emotional wellness and cognitive function, particularly during times of stress or hormonal changes.
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