Wong et al. (2011) Study Analysis
Comprehensive Review: Bioactive Compounds & Cognitive Benefits
Lion's Mane (Hericium erinaceus) - Comprehensive Analysis of Medicinal Properties
Full Citation
Wong, K. H., Naidu, M., David, P., Abdulla, M. A., Abdullah, N., Kuppusamy, U. R., & Sabaratnam, V. (2011). Neuroregenerative potential of lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers., in the treatment of neurological disorders. International Journal of Medicinal Mushrooms, 13(5), 427-446.
DOI: 10.1615/IntJMedMushr.v13.i5.10 | PubMed ID: 22164752
Study Type
- Type: Comprehensive Review
- Focus: Bioactive compounds analysis
- Scope: Neuroregenerative potential
- Approach: Literature synthesis
Key Compounds
- Hericenones: NGF-stimulating compounds
- Erinacines: Blood-brain barrier crossing
- Polysaccharides: Neuroprotective effects
- Beta-glucans: Immune modulation
Research Areas
- Neuroregeneration: Nerve growth factor
- Neuroprotection: Brain cell protection
- Cognitive Function: Memory and learning
- Neurological Disorders: Therapeutic potential
Key Findings
Compounds Identified
Factor Stimulation
Protection
Neurological Health
Clinical Significance
This comprehensive review establishes the scientific foundation for Lion's Mane's neuroregenerative and neuroprotective properties. The study identifies key bioactive compounds including hericenones and erinacines that stimulate nerve growth factor (NGF) production and support brain health.
The research demonstrates that Lion's Mane contains unique compounds that can cross the blood-brain barrier and directly support neural health, making it particularly valuable for cognitive function, memory enhancement, and neurological wellness.
Safety Profile
- Safety: Well-documented safety profile
- Tolerability: Excellent, natural compound
- Traditional Use: Centuries of safe use
What This Means for You
This research provides strong scientific evidence for Lion's Mane's role in supporting brain health and cognitive function. The identification of specific bioactive compounds like hericenones and erinacines helps explain how Lion's Mane works to support nerve growth and brain cell protection. This comprehensive analysis suggests that Lion's Mane may be valuable for maintaining cognitive health, supporting memory, and promoting neurological wellness as part of a healthy lifestyle.
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